IBD-Derived Colonic Fibroblasts Exhibit an Osteopontin-Enriched Secretome, and Osteopontin Restrains Human Colonic Organoid Maturation
Dimitri Hamel, Muriel Quaranta, Delphine Bonnet, Laurent Alric, Audrey Ferrand
This study identifies an osteopontin-enriched secretome in IBD-derived colonic fibroblasts and shows that OPN impairs epithelial maturation in human colonic organoids.
bioRxiv · Sep 3, 2026 · PreprintPhysiology