Author

Murphy DeMeglio

Goethe University Frankfurt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Christina Sauerland· 2 shared Eloah S. De Biasi· 2 shared Jasmin K. HefendehliD· 2 shared Michael CandlishiD· 2 shared Peter BreunigiD· 2 shared Stefan GüntheriD· 2 shared Amparo Acker‐PalmeriD· 1 shared Andreas G. ChiocchettiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersNeuroscience

Christina Sauerland

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2 papers

Recent·Most cited

Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology

Michael Candlish, Jan C. Hofmann, Desirée Brösamle, Annika Haessler, Murphy DeMeglio, Angelos Skodras, Georgi Tushev, Eloah S. De Biasi, Stefan Günther, René Wiegandt, Heidi Theis, Elena De Domenico, Nina Sofia Hermann, Peter Breunig, Christina Sauerland, , Jasmin K. Hefendehl

The paper investigates how ischemic injury affects microglial response to Aβ pathology, finding a protective microglial phenotype that promotes benign Aβ plaque formation.

Journal of Neuroinflammation · Jun 9, 2026Peer-reviewedNeuroscience

Soluble epoxide hydrolase upregulation in Alzheimer's disease promotes blood-brain barrier dysfunction

Murphy DeMeglio, Eloah S. De Biasi, Peter Breunig, Michael Candlish, Christina Sauerland, Stefan Günther, Haruya Kawase, Blanca Peguera, Christine Bohnstaedt, Peter R. Nilsson, Jiong Hu, Susanne S. Hille, Oliver J Mueller, Amparo Acker‐Palmer, Bruce D. Hammock, , Jasmin K. Hefendehl

This study shows that soluble epoxide hydrolase in astrocytes contributes to vascular instability in Alzheimer's disease, and its deletion reduces vascular amyloid burden and preserves vascular structure.

bioRxiv · Dec 11, 2025 · PreprintNeuroscience