Principles of subclonal gene dosage across human cancer
Sólrún Kolbeinsdóttir, Vasilios Zachariadis, Muyi Yang, Luuk A. Broeils, Christian Sommerauer, Huaitao Cheng, Xinsong Chen, Yingbo Lin, Matías Marín Falco, Johanna Hynninen, Sampsa Hautaniemi, Yizhe Sun, Olli Lohi, Merja Heinäniemi, Suzanne Egyhazi Brage, , Martin Enge
The paper analyzes subclonal gene dosage effects in cancer using DNTR-seq, finding additive and compensatory transcriptional impacts and identifying transient clonality in ovarian and soft tissue sarcomas.
bioRxiv · Mar 18, 2026 · PreprintCancer Biology