APC loss promotes intestinal transformation through induction of bistable stem cell states
N Li, RL Myers, Qin Zhu, Ye Tian, Kayla Durning, X Wang, NA Leu, JH Rhoades, Devon Bankler-Jukes, Keara Monaghan, Stephanie Adams‐Tzivelekidis, Oz Pomp, Oscar Pellón-Cárdenas, Mario Andres Blanco, Michael Paul Verzi, , Christopher J. Lengner
This study identifies that APC loss in colorectal cancer drives a β-CATENIN-independent fetal intestinal transcriptional program through YAP activation, leading to bistable stem cell states and enhanced tumorigenesis.
bioRxiv · Mar 6, 2025 · PreprintCancer Biology