Author

X Wang

AbbVie (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Immunology· 1 Microbiology· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Aicha Abdourahman· 1 shared Akhila Gundavelli· 1 shared Alberto Serrano‐PozoiD· 1 shared Annita Martin· 1 shared Astrid Doering· 1 shared Bingqing LiiD· 1 shared Bradley T. HymaniD· 1 shared Caitlin Brandle· 1 shared

Activity by Year

2015-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperNeuroscience

Aicha Abdourahman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer's Disease and Primary Tauopathies

L. Daniel Estrella, Swarnali Dasgupta, Akhila Gundavelli, Huan Li, Stanley Yang, Sarah E. Chancellor, Tim Pastika, Aicha Abdourahman, Joseph A. Tamm, Kiran Yanamandra, Nandani Romanul, Fan Liao, Karen Zhao, Gen Lin, Pooja Srinivasa, , Rachel E. Bennett

The paper uses single-nucleus RNA-seq to analyze cerebrovascular transcriptomic changes in Alzheimer's Disease and primary tauopathies, identifying shared heat-shock responses and disease-specific vascular remodeling.

bioRxiv · Jun 28, 2026 · PreprintNeuroscience

Oxytocin treats respiratory depression and reduces mortality from fentanyl and the combination of xylazine-fentanyl

Joan B. Escobar, John Wainwright, X Wang, Olga Dergacheva, Matthew W. Kay, John R. Bethea, Vivek Jain, Vsevolod Y. Polotsky, David Mendelowitz

This study shows oxytocin improves survival and respiratory function in rats with opioid-induced respiratory depression caused by fentanyl or fentanyl-xylazine combinations, outperforming naloxone in some cases.

bioRxiv · Feb 24, 2026 · PreprintPharmacology & Toxicology

Salmonella exploits metal-responsive UMPylation to enable intracellular biphasic growth and antibiotic tolerance

Weiwei Wang, H L Jia, Yongyu Wang, Qingjie Bai, Ruirui Liu, Ting Sun, Yingying Yue, X Wang, Yunzhuo Zhao, Xiaoyu Liu, Xilu Yuan, Rongxian Xie, Nannan Song, Yuzhen Wang, Zhongrui Ma, , Bingqing Li

This paper identifies a metal-responsive UMPylation mechanism in Salmonella that enables intracellular biphasic growth and antibiotic tolerance by modulating protein aggregation and translational arrest.

bioRxiv · Feb 10, 2026 · PreprintMicrobiology

Indomethacin exerts both cyclooxygenase inhibition-dependent and independent mechanisms to enhance chemo-immunotherapy in mice

Ogacheko D. Okoko, Nada S. Aboelella, Yan Ye, X Wang, Samson Eugin Simon, Md Yeashin Gazi, Victor J. Victor J. Enriquez Castro, Mercy Kehinde‐Ige, Caitlin Brandle, Dongwen Lv, David W. Wolff, Catherine C. Hedrick, Gary Anthony Piazza, Huidong Shi, Gang Zhou

This study shows indomethacin enhances chemo-immunotherapy in mice through both COX-dependent and independent mechanisms, including RAS inhibition.

bioRxiv · Jan 8, 2026 · PreprintImmunology

APC loss promotes intestinal transformation through induction of bistable stem cell states

N Li, RL Myers, Qin Zhu, Ye Tian, Kayla Durning, X Wang, NA Leu, JH Rhoades, Devon Bankler-Jukes, Keara Monaghan, Stephanie Adams‐Tzivelekidis, Oz Pomp, Oscar Pellón-Cárdenas, Mario Andres Blanco, Michael Paul Verzi, , Christopher J. Lengner

This study identifies that APC loss in colorectal cancer drives a β-CATENIN-independent fetal intestinal transcriptional program through YAP activation, leading to bistable stem cell states and enhanced tumorigenesis.

bioRxiv · Mar 6, 2025 · PreprintCancer Biology

Efficient Assembly and Verification of ZFNs and TALENs for Modifying Porcine ApoE gene

H R Xu, T Li, Y Guo, H F Li, L Wang, Z Y Zhang, X Wang

This study develops and validates ZFNs and TALENs for efficient genome editing of the ApoE gene in human cells.

bioRxiv · Jan 13, 2015 · PreprintBioengineering