Frizzled-4 regulates β-catenin in endothelial cells exposed to disturbed flow via an atypical Wnt pathway leading to proinflammatory activation and increased permeability
M. Rickman, M. Ghim, K. Tian Pang, A. C. von Huelsen Rocha, E. M. Drudi, M. Sureda-Vives, N. Ayoub, V. Tajadura-Ortega, S. J. George, P. D. Weinberg, C. M. Warboys
This study shows that Frizzled-4 and RSPO-3 mediate an atypical Wnt pathway in endothelial cells under multidirectional flow, leading to β-catenin stabilization, inflammation, and increased permeability.
bioRxiv · Nov 12, 2021Cell Biology