A SREBF2-dependent gene program drives an immunotolerant dendritic cell population during cancer progression
M. P. Plebanek, Y. Xue, Y.-V. Nguyen, N. DeVito, X. Wang, A. Holtzhausen, G. Beasley, N. Yarla, B. Theivanthiran, B. A. Hanks
The paper identifies SREBF2 as a regulator of mregDC development and function in the tumor microenvironment, highlighting it as a therapeutic target for immune tolerance.
bioRxiv · Apr 26, 2023 · PreprintImmunology