N. Fluman

Membrane-embedded polar residues target membrane proteins for degradation by the quality control protease FtsH

The paper identifies how lipid-facing polar residues direct membrane proteins to FtsH-mediated degradation in E. coli, revealing a mechanism for recognizing misfolded proteins.

Membrane protein sequence features direct post-translational insertion

The paper shows that C-terminal tails of membrane proteins influence post-translational insertion of transmembrane helices, with sequence changes causing functional defects and disease.

Dynamic membrane topology in an unassembled membrane protein

This study shows that monomeric SMR proteins exhibit topological dynamics, with the N-terminal transmembrane helix switching between inserted and non-inserted states, and this dynamics is lost upon dimerization.

Stable Membrane Topologies Of Small Dual-Topology Membrane Proteins

This study investigates whether monomers of anti-parallel homo- or hetero-dimeric Small Multidrug Resistance proteins can undergo reversible topological inversion in the membrane, finding that dimerization does not affect their final topology.