MAPK11 (p38β) is a major determinant of cellular radiosensitivity by enhancing IR-associated senescence.
D. M. Fernandez-Aroca, N. Garcia-Flores, S. Frost, J. Jimenez-Suarez, A. Rodriguez-Gonzalez, P. Fernandez-Aroca, S. Sabater, I. Andres, C. Garnes-Garcia, B. Belandia, F. J. Cimas, D. Villar, M. J. Ruiz-Hidalgo, R. Sanchez-Prieto
This paper shows that MAPK11 enhances radiosensitivity by promoting IR-induced senescence without affecting DNA damage response or apoptosis in cancer cells.
bioRxiv · Sep 12, 2022 · PreprintCancer Biology