Prostaglandin E2 production is required for phagocyte CXCR2-mediated skin host defense in obese hyperglycemic mice.
N. Klopsfenstein, K. Hibbs, A. Blackman, C. Serezani
This study shows that restoring PGE2 levels with misoprostol improves infection outcomes in obese hyperglycemic mice by enhancing CXCR2-mediated phagocyte recruitment.
bioRxiv · Oct 2, 2022 · PreprintImmunology