Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer
B. R. Ford, N. L. Rittenhouse, N. E. Scharping, P. D. A. Vignali, A. T. Frisch, R. Peralta, G. M. Delgoffe, A. C. Poholek
This study identifies epigenetic changes in exhausted T cells during tumor infiltration, showing they are driven by altered costimulatory signals and hypoxia, which limit their transcriptional potential.
bioRxiv · Jul 11, 2021 · PreprintImmunology