Author

P. D. A. Vignali

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Immunology· 1

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Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. C. Poholek· 1 shared A. T. Frisch· 1 shared B. R. Ford· 1 shared G. M. Delgoffe· 1 shared N. E. Scharping· 1 shared N. L. Rittenhouse· 1 shared R. Peralta· 1 shared

Activity by Year

2021-2021 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. C. Poholek

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintJul 11, 2021

Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer

B. R. Ford, N. L. Rittenhouse, N. E. Scharping…·A. C. Poholek

This study identifies epigenetic changes in exhausted T cells during tumor infiltration, showing they are driven by altered costimulatory signals and hypoxia, which limit their transcriptional potential.

DOI 10.1101/2021.07.11.451947

humanChIP-seq

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