Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
N. Lopes, N. Boucherit, J. Charaix, P. Ferrier, M. Giraud, M. Irla
The paper shows self-reactive CD4+ thymocytes regulate gene expression and subset composition in immature medullary thymic epithelial cells through histone modifications and transcriptional regulators.
bioRxiv · Nov 29, 2020Immunology