Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope
L. Villiger, L. Schmidheini, N. Mathis, T. Rothgangl, K. Marquart, G. Schwank
This study replaces the SpCas9 HNH domain with deaminases to create smaller base editors with expanded targeting scope.
bioRxiv · Nov 9, 2020Bioengineering