Author

L. Schmidheini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

G. Schwank· 2 shared L. Villiger· 2 shared T. Rothgangl· 2 shared A. Cremonesi· 1 shared A. Talas· 1 shared B. Thoeny· 1 shared C. Schwerdel· 1 shared D. Boeck· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

G. Schwank

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Treatment of a genetic liver disease in mice through transient prime editor expression

T. Rothgangl, E. I. Ioannidi, Y. Weber, A. Talas, D. Boeck, M. Matsushita, E. A. Villiger, L. Schmidheini, J. Moon, P. J. C. Lin, S. H. Y. Fan, K. F. Marquart, C. Schwerdel, N. Rimann, E. Faccin, , G. Schwank

This paper demonstrates transient prime editor expression in mice to correct a genetic liver disease, reducing blood phenylalanine levels below the therapeutic threshold.

bioRxiv · Jan 22, 2024 · PreprintBioengineering

Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope

L. Villiger, L. Schmidheini, N. Mathis, T. Rothgangl, K. Marquart, G. Schwank

This study replaces the SpCas9 HNH domain with deaminases to create smaller base editors with expanded targeting scope.

bioRxiv · Nov 9, 2020Bioengineering