Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia
I. Baccelli, Y. Gareau, B. Lehnertz, S. Gingras, J.-F. Spinella, A. Beautrait, S. Corneau, N. Mayotte, I. Boivin, S. Girard, T. MacRae, M. Frechette, K. Leveille, J. Krosl, C. Thiollier, , G. Sauvageau
The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.
bioRxiv · Jan 15, 2019 · PreprintCancer Biology