S. Gingras

Proteolytic Cleavage of the ENaC gamma Subunit: Impact Upon Na+ and K+ Handling

This study investigates the impact of proteolytic cleavage of the ENaC gamma subunit on Na+ and K+ handling in mice, finding that cleavage is not essential for channel activity in vivo.

Arid5a mediates an IL-17-dependent pathway that drives autoimmunity but not antifungal host defense

This study shows Arid5a promotes IL-17-dependent autoimmunity but not antifungal immunity, suggesting targeted therapy could reduce autoimmune side effects.

A loss-of-function mutation in IL-17F enhances susceptibility of mice to oropharyngeal candidiasis

This study shows that a loss-of-function mutation in IL-17F increases susceptibility to oropharyngeal candidiasis in mice, but not in heterozygous carriers.

Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia

The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.