Structural mechanisms of drebrin-mediated F-actin network modulation
W. Zhao, LY Chu, Giancarlo Abis, Fazal Oozeer, Thomas Mulvaney, N. Nagar, Maya Topf, Phillip R. Gordon‐Weeks, MR Conte, Joseph Atherton
This study uses cryo-EM to reveal drebrin's structural interaction with F-actin through two domains, explaining its modulatory role in actin networks and competitive binding with other proteins.
Nature Communications · Jun 23, 2026Peer-reviewedBiochemistry