Selective sweep and phylogenetic models for the emergence and spread of pyrimethamine resistance mutations in Plasmodium vivax
A. Shaukat, Q. Ali, T. Connelley, M. A. Ullah Khan, M. A. Saleem, I. Rashid, N. Sargison, U. Chaudhry
The paper identifies positive selection pressure and selective sweeps for pyrimethamine resistance mutations in Plasmodium vivax in Pakistan, showing both single and recurrent emergence of resistance haplotypes.
bioRxiv · Oct 3, 2018Evolutionary Biology