Cell BiologybioRxivPreprint
Microtubule binding-induced allostery promotes LIS1 dissociation from dynein prior to cargo transport
W. D. Ton, Y. Wang, P. Chai…·S. M. Markus
The paper investigates how microtubule binding affects LIS1 dissociation from dynein, showing that MT-bound dynein has low LIS1 affinity while MT-unbound dynein binds LIS1 strongly.
DOI 10.1101/2022.11.08.515461