K. Zhang

Intracellular lipopolysaccharide binds RETREG1/FAM134B to regulate ER remodeling upon bacterial infection

This study shows that bacterial LPS binds RETREG1 to induce ER remodeling and enhance antibacterial defense through ERphagy.

Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma

This study shows that the cell of origin in lung adenocarcinoma affects the immunosuppressive state of the tumor microenvironment, with AT1-derived tumors showing an anti-tumor immune profile and AT2-derived tumors showing immunosuppressive features.

Oligopeptide (FK)4 facilitates the determination of the absolute stereochemistry of chiral organic compounds via NMR Spectroscopy

This study demonstrates how the oligopeptide (FK)4 enables the determination of absolute stereochemistry of chiral compounds using NMR spectroscopy by combining alignment medium and chiral differentiating properties.

MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi

This study identifies MCP5 as essential for Borrelia burgdorferi's immune evasion and transmission, regulated by two signaling pathways.

Emergent digital bio-computation through spatial diffusion and engineered bacteria

This paper designs bacterial computers using spatial diffusion and engineered Escherichia coli to perform digital logic operations and complex computations.

Real-time Biomechanical Characterisation of Cytoskeletal Remodelling

This study uses Q-AFM to track real-time biomechanical changes in hMSCs during cytoskeletal remodelling induced by disruptors.

SspA is a transcriptional regulator of CRISPR adaptation in E. coli

This study identifies SspA as a transcriptional regulator of CRISPR adaptation in E. coli using a CRISPRi-based screen and proposes a model of independent cellular control of adaptation and interference by SspA.

The dual resistance mechanism of CYP325G4 and CYP6AA9 in Culex pipiens pallens legs according to transcriptome and proteome analysis

This study identifies CYP325G4 and CYP6AA9 as key P450 enzymes involved in deltamethrin resistance in Culex pipiens legs through transcriptome and proteome analysis.

Cryo-EM Reveals the Mechanochemical Cycle of Reactive Full-length Human Dynein-1

The paper uses cryo-EM to study the mechanochemical cycle of full-length human dynein-1, revealing over 40 high-resolution structures and new mechanistic insights.

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

Multi-Omics Analysis Reveals the Attenuation of the Interferon Pathway as a Driver of Chemo-Refractory Ovarian Cancer

The paper identifies reduced IFN-I pathway activity as a driver of chemo-refractory ovarian cancer using multi-omics analysis in a clinical trial cohort.

Targeting Fatty Acid Desaturase I Inhibits Renal Cancer Growth Via ATF3-mediated ER Stress Response

This study shows that inhibiting FADS1 reduces renal cancer growth by inducing ER stress and ATF3-mediated responses, highlighting FADS1 as a therapeutic target.

Efficient differentiation of human retinal pigment epithelium cells from chemically induced pluripotent stem cells

This study develops a chemical method to generate hCiPSCs and demonstrates their efficient differentiation into RPE cells for AMD treatment.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

DERIVATION OF ELEPHANT INDUCED PLURIPOTENT STEM CELLS

This paper reports the first derivation of elephant induced pluripotent stem cells (emiPSCs) using a modified reprogramming protocol that inhibits TP53 expansion genes.

Immunomagneto-activated hepatocyte-specific tissue vesicle profiling reveals message diversification from regenerating liver

The paper identifies hepatocyte-derived extracellular vesicles (Hep-EVs) as critical regulators of liver regeneration, showing they promote hepatocyte proliferation through Cdk1 activity and offer therapeutic potential.

Targeted NAD+ Delivery for Intimal Hyperplasia and Re-endothelialization: A Novel Anti-restenotic Therapy Approach

This study demonstrates that targeted NAD+ delivery via nanocarriers reduces intimal hyperplasia and promotes endothelial regeneration in a rat model of restenosis.

Beige adipose tissue-derived extracellular vesicles: a potent metabolic regulator and a novel remedy for nonalcoholic fatty liver disease

This study isolates and characterizes beige adipose tissue-derived extracellular vesicles (BeEVs) and shows they improve metabolic dysfunction in a nonalcoholic fatty liver disease model.

Phosphatidylinositol 3-phosphate mediates Arc capsids secretion through the multivesicular body pathway

This study identifies the endosomal-multivesicular body (MVB) pathway as the secretion route for Arc capsids, mediated by phosphatidylinositol-3-phosphate (PI3P).

Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility

This study identifies LRRC23 as a critical component of the RS3 head in mammalian sperm, showing that its truncation leads to defective flagellar motility and male infertility.

Tissue stiffness mapping by light sheet elastography

This paper introduces light sheet elastography to map tissue stiffness in embryos, enabling noninvasive, high-resolution analysis of mechanical changes during development.

Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses

This paper determines the 3D structures of SL5 RNA domains from six coronaviruses, revealing conserved tertiary features with implications for protein-binding and antiviral targets.

Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA

This paper shows HPV16 replication converts SAMHD1 into a homologous recombination factor by phosphorylation, enhancing its recruitment to viral DNA and reducing replication.

Climate warming suppresses soil abundant fungal taxa and reduces soil carbon efflux in a semi-arid grassland

This study shows that warming reduces fungal abundance and shifts fungal community composition in semi-arid grasslands, leading to reduced soil carbon efflux.

FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS

This study shows that overproducing cMYC in TP53 and RB1-depleted hESC-derived PNECs leads to aggressive SCLC-like tumors with metastatic properties and NEUROD1 expression.

Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation

The paper shows CAM-A modulators eliminate HBV-infected hepatocytes with high core antigen levels via apoptosis, dependent on de novo core protein translation.

SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication

This study shows PIAS1 promotes YTHDF2 SUMOylation, enhancing its anti-EBV activity by reducing viral mRNA stability.

Interchromosomal Colocalization with Parental Genes Is Linked to the Function and Evolution of Mammalian Retrocopies

This study shows that retrocopies and their parental genes colocalize in 3D genome organization, leading to increased transcription, translation, and evolutionary conservation.

MEILB2-BRME1 forms a V-shaped DNA clamp upon BRCA2-binding in meiotic recombination

The paper reports the crystal structure of MEILB2-BRME1 complex and shows how BRCA2 binding causes it to form a V-shaped DNA clamp to facilitate meiotic recombination.