Megakaryocyte infection by SARS-CoV-2 drives the formation of pathogenic afucosylated IgG antibodies in mice
M. Mabrouk, F. Jalali, N. Zaid, A. Naya, M. Khyatti, L. Khalki, F. Guessous, Y. Zaid
This study shows that SARS-CoV-2-infected megakaryocytes in mice drive the production of pathogenic afucosylated IgG antibodies, leading to severe COVID-19-like symptoms.
bioRxiv · Jul 14, 2023 · PreprintImmunology