Functional analyses of phosphatidylserine/PI(4)P exchangers with diverse lipid species and membrane contexts set unanticipated rules on lipid transfer
S. Ikhlef, N.-F. Lipp, V. Delfosse, N. Fuggetta, W. Bourguet, M. Magdeleine, G. Drin
This study investigates how lipid transfer proteins exchange phosphatidylserine and phosphatidylinositol 4-phosphate, revealing that their transfer speed inversely depends on ligand affinity and that they cannot use PI(4,5)P2 for exchange.
bioRxiv · Jul 16, 2021Biochemistry