Author

D. Debayle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 9 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:proteomics· 8 Research Focus:cell type annotation· 6 Research Focus:cell signaling & trafficking· 5 Organism:human· 5 Assay:metabolomics· 4 Research Focus:differential expression· 3 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

L. Fleuriot· 8 shared B. Antonny· 5 shared A.-S. Gay· 4 shared B. Mesmin· 3 shared S. Lacas-Gervais· 3 shared A. Patel· 2 shared A. R. Dias Araujo· 2 shared D. Kovacs· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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8 shared papersCell Biology

L. Fleuriot

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Acyltransferases in the first step of glycerophospholipid synthesis have redundant and non-redundant roles in sn-1 acyl chain regulation, ether lipid levels, and cell survival

S. Salame, H. Qasmaoui, G. P. Jose, L. Fleuriot, D. Debayle, T. Harayama

The paper investigates the roles of GPATs and GNPAT in lipid synthesis, showing their impact on ether lipid levels, acyl chain regulation, and cell survival.

bioRxiv · Jan 17, 2024 · PreprintCell Biology

FAO-supported OxPhos leukemic stem cells are sensitive to cold.

E. Griessinger, D. Pereira-Martins, M. Nebout, C. Bosc, E. Saland, E. Boet, A. Sahal, J. Chiche, D. Debayle, L. Fleuriot, M. Pruis, V. De Mas, F. Vergez, C. Recher, G. Huls, , J.-F. Peyron

The paper identifies cold sensitivity as a vulnerability in FAO-supported OxPhos leukemic stem cells, which can be exploited for therapeutic targeting.

bioRxiv · Apr 17, 2023 · PreprintCancer Biology

Multiomics study of CHCHD10S59L-related disease reveals energy metabolism downregulation: OXPHOS and beta-oxidation deficiencies associated with lipids alterations

B. Madji Hounoum, R. Bellon, E. C. Genin, S. Bannwarth, A. Lefevre, L. Fleuriol, D. Debayle, A.-S. Gay, A. Petit-Paitel, S. Lacas-Gervais, H. Blasco, P. Edmond, V. Paquis-Flucklinger, J.-E. RICCI

This study identifies metabolic and lipid alterations in CHCHD10S59L-related disease, showing OXPHOS and beta-oxidation deficiencies and suggesting L-acetylcarnitine as a potential therapeutic.

bioRxiv · Jan 19, 2023 · PreprintCell Biology

VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites

M. Subra, M. Dezi, J. Bigay, S. Lacas-Gervais, A. Di Cicco, A. R. Dias Araujo, S. Abelanet, L. Fleuriot, D. Debayle, R. Gautier, A. Patel, F. Roussi, B. Antonny, D. Levy, B. Mesmin

This study shows that VAP-A's intrinsically disordered regions enable its versatile localization at different membrane contact sites by adjusting geometry to MCS organization and lifetime.

bioRxiv · May 13, 2022Cell Biology

OSBP-mediated cholesterol transfer determines epithelial polarity and associated cargo secretion

D. Kovacs, A.-S. Gay, L. Fleuriot, D. Debayle, A. R. Dias Araujo, A. J. Patel, B. Mesmin, F. Luton, B. Antonny

This study shows OSBP-mediated cholesterol transfer is essential for epithelial polarity and cargo secretion, with OSBP inhibition disrupting apico-basal polarity and E-cadherin secretion.

bioRxiv · Dec 9, 2021 · PreprintCell Biology

Tumor protein D54 binds intracellular nanovesicles via an amphipathic lipid packing sensor (ALPS) motif

A. Reynaud, M. Magdeleine, A. Patel, A.-S. Gay, D. Debayle, S. Abelanet, B. Antonny

This study identifies an ALPS motif in TPD54 that enables its binding to intracellular nanovesicles, distinct from vesicles targeted by GMAP-210.

bioRxiv · Dec 3, 2021 · PreprintCell Biology

Docosahexaenoic fatty acid-containing phospholipids affect plasma membrane susceptibility to disruption by bacterial toxin-induced macroapertures

M.-C. TSAI, L. FLEURIOT, S. JANEL, D. GONZALEZ-RODRIGUEZ, C. MOREL, A. METTOUCHI, D. DEBAYLE, S. DALLONGEVILLE, J.-C. OLIVO-MARIN, B. ANTONNY, F. LAFONT, E. LEMICHEZ, H. BARELLI

The paper shows that DHA-containing phospholipids increase macroaperture formation in endothelial cells by reducing cell thickness, while maintaining overall transcellular area.

bioRxiv · Dec 23, 2020 · PreprintCell Biology

UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFRsignaling

S. TORRINO, V. TIROILLE, B. DOLFI, M. DUFIES, C. HINAULT, L. BONESSO, S. DAGNINO, J. P. UHLER, M. IRONDELLE, A.-S. GAY, L. FLEURIOT, D. Debayle, S. LACAS-GERVAIS, M. CORMONT, T. BERTERO, , S. CLAVEL

This study shows UBTD1 regulates EGFR signaling by controlling ceramide levels and endolysosomal positioning through ubiquitination of ASAH1 and SQSTM1/p62.

bioRxiv · May 20, 2020Cell Biology

Osh6 requires Ist2 for localization to the ER-PM contacts and efficient phosphatidylserine transport

J. M. D'Ambrosio, V. Albanese, N.-F. Lipp, L. FLEURIOT, D. Debayle, G. Drin, A. Copic

bioRxiv · Jan 31, 2020Cell Biology

Molecular and cellular dissection of the OSBP cycle through a fluorescent inhibitor

T. Péresse, D. Kovacs, M. Subra, J. Bigay, M.-C. Tsai, J. Polidori, R. Gautier, S. Desrat, L. Fleuriot, D. Debayle, M. Litaudon, V. C. Pham, J. Bignon, B. Antonny, F. Roussi, B. Mesmin

The paper uses a fluorescent inhibitor to study OSBP lipid exchange and its effects on cellular processes.

bioRxiv · Nov 20, 2019 · PreprintCell Biology