Foxh1 is a locus-specific PRC2 recruiter governing germ layer silencing
Jin Cho, Clark L. Hendrickson, Nathan Mar, Ira L. Blitz, Margaret B. Fish, Wenqi Wang, Ken W.Y. Cho
This study shows Foxh1 recruits PRC2 to specific loci, silencing genes in ectoderm while activating them in endoderm during early embryogenesis.
bioRxiv · Sep 21, 2025 · PreprintDevelopmental Biology