Programmable RNA writing with trans-splicing
Cian Schmitt-Ulms, Alişan Kayabölen, Marcos Manero-Carranza, Nathan Zhou, Keira A. Donnelly, Sabrina Pia Nuccio, Kazuki Kato, Hiroshi Nishimasu, Jonathan S. Gootenberg, Omar O. Abudayyeh
This paper introduces PRECISE, a method for programmable RNA editing that enables precise insertion, substitution, and deletion of RNA sequences in pre-mRNAs, with high efficiency and fidelity.
bioRxiv · Jan 31, 2024 · PreprintMolecular Biology