PIANO: Probabilistic Inference Autoencoder Networks for multi-Omics enables robust generative modeling of gene expression and scales single-cell integration to 100 million cells
Ning Wang, Christopher Cardenas, Victor Eduardo Nieto Caballero, David Turner, Hannah Feinberg, Dan Yuan, Nathaniel Scott, Michael DeBerardine, Shu Dan, Lakme Caceres, Jessica Schembri, Zizhen Yao, Changkyu Lee, Jonathan W. Pillow, Fenna M. Krienen
PIANO integrates single-cell data across species and modalities, models gene expression, and scales to 100 million cells for drug perturbation analysis.
bioRxiv · Aug 12, 2026 · PreprintBioinformatics