Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3
Nazli Akilli, Paul-Swann Puel, Marco Di Stefano, Fernando Muzzopappa, Lauriane Fritsch, Fabian Erdel, Daniel Jost, Thierry Cheutin, Giacomo Cavalli
This study shows that SUMOylation loss in Drosophila disrupts PRC1 condensates, causing 3D genome rewiring and gene misregulation without affecting H3K27me3 levels.
Nucleic Acids Research · Aug 23, 2026Peer-reviewedGenomics