SOP-Multi-π: A Two-Site Coarse-Grained Model with Rescaled Aromatic Interactions to Bridge Single-Chain Ensembles and Condensate Phase Behavior of IDPs and Multidomain Proteins
Santosh Prajapati, Neha Mathur, Debayan Chakraborty, Anand Srivastava
The paper introduces SOP-Multi-π, a coarse-grained model with rescaled aromatic interactions to better simulate IDPs and their phase behavior in condensates.
bioRxiv · Oct 1, 2026 · PreprintBiophysics