Highly conserved talin isoforms encode distinct mechanical responses and ligand-binding capabilities
Yanyu Guo, Durgarao Guttula, Mingxi Yao, Daniel M. Cooper, Neil Ball, Benjamin Klapholz, Alexa Price, Alan Howe, Benjamin T. Goult, Jie Yan
This study examines how sequence differences between talin-1 and talin-2 affect their mechanical responses and ligand-binding capabilities, revealing distinct mechanical behaviors and new interaction sites in talin-2.
bioRxiv · Nov 6, 2026 · PreprintBiophysics