The free fatty acid 2 receptor regulates the activation potency of C5a and the sensitivity to the antagonist avacopan
Zahra Khan, Neil Levin, Cláes Dahlgren, Martina Sundqvist, Fariha Khan, Huamei Fu Forsman, Lena I Björkman
This study shows that the free fatty acid 2 receptor modulates C5a receptor signaling, enhancing NADPH oxidase activation and reducing the effect of the antagonist avacopan.
bioRxiv · Oct 28, 2025 · PreprintCell Biology