The free fatty acid 2 receptor regulates the activation potency of C5a and the sensitivity to the antagonist avacopan
Zahra Khan, Neil Levin, Cláes Dahlgren…·Lena I Björkman
This study shows that the free fatty acid 2 receptor modulates C5a receptor signaling, enhancing NADPH oxidase activation and reducing the effect of the antagonist avacopan.