Author

Nhu Le

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Emma J. HedgepethiD· 2 shared Laurence Crane EisenlohriD· 2 shared Mary E. O'Mara· 2 shared Stephen D. CarroiD· 2 shared Chaitali BhadiadraiD· 1 shared Christabel Ameyaw Baah· 1 shared Coral M. KasdeniD· 1 shared Hansell H. StedmaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Emma J. HedgepethORCID

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2 papers

Recent·Most cited

Generation and MHC class II loading of an endogenous influenza epitope revealed by a T cell receptor-like antibody

Linlin Yang, Michael John Hogan, Stephen D. Carro, Emma J. Hedgepeth, Jianqiu Du, Mary E. O'Mara, Kathleen S Krauss, Robert Novak, Christabel Ameyaw Baah, Nhu Le, Chaitali Bhadiadra, Jesper Pallesen, Laurence Crane Eisenlohr

An mRNA vaccine-based pipeline generated a TCR-like antibody to study noncanonical MHC-II antigen processing of an influenza epitope.

bioRxiv · Jul 2, 2026 · PreprintImmunology

Endogenous antigen processing promotes mRNA vaccine CD4+ T cell responses

Julia E. Rood, Suh Kyung Yoon, Mary K. Heard, Stephen D. Carro, Emma J. Hedgepeth, Mary E. O'Mara, Michael J. Hogan, Nhu Le, Hiromi Muramatsu, Kieu Lam, Petra Schreiner, Coral M. Kasden, Hansell H. Stedman, Ryan Andrew Langlois, James Heyes, , Laurence Crane Eisenlohr

This study shows that endogenous antigen processing via MHC II is critical for mRNA-LNP vaccine-induced CD4+ T cell responses, challenging the traditional view of exogenous antigen processing.

bioRxiv · Mar 11, 2025 · PreprintImmunology