Trade-offs between phage resistance and conjugative ability shape the ecological and evolutionary response of a multidrug resistance plasmid to plasmid-dependent phage
Daniel Cazares, Eliza Rayner, Adrián Cazares, Wendy Figueroa, David Goulding, Samuel T. E. Greenrod, Adam J. Mulkern, Michelle Yin, Tao He, Nick Thomson, Michael A. Brockhurst, R. Craig MacLean
This study shows that multidrug resistance plasmids face a trade-off between phage resistance and conjugative ability, which affects their evolutionary response to plasmid-dependent phages.
bioRxiv · Oct 8, 2025 · PreprintEvolutionary Biology