Tao He

Plasmid dependent phage eliminate pathogenic bacteria and antibiotic resistance plasmids from the chicken gut microbiome

This study shows that plasmid-dependent phage treatment removes pathogenic bacteria and antibiotic resistance plasmids from chicken gut microbiomes without disrupting overall microbiome composition.

Trade-offs between phage resistance and conjugative ability shape the ecological and evolutionary response of a multidrug resistance plasmid to plasmid-dependent phage

This study shows that multidrug resistance plasmids face a trade-off between phage resistance and conjugative ability, which affects their evolutionary response to plasmid-dependent phages.

Single-Cell Sequencing Identifies the Crucial Role of Mitochondrial Fission-Fusion Balance in Cardiac Hypertrophy Progression

The paper uses single-cell and bulk RNA sequencing to compare pathological and physiological cardiac hypertrophy, finding that mitochondrial fission genes drive pathological progression.

A Simple Approximation To The Bias Of Gene-Environment Interactions In Case/Control Studies With Silent Disease

The paper derives a theoretical approximation for bias in gene-environment interaction estimates in case-control studies with silent disease and validates it through simulations and a prostate cancer study.

An optimal kernel-based method for gene set association analysis

The paper introduces an efficient kernel-based method for gene set association analysis that controls type I error and achieves high power in high-dimensional settings.