Tirzepatide improves pancreatic β-cell function in mice and patients with type 2 diabetes.
Zhehui Li, Jiacheng Guo, Ying Cheng, Tongyu Zhang, Xiumei Luo, Shuyi Zhang, Qi Ren, Zhiqiang Wu, Ning Chen, Mingyu Li
This study shows tirzepatide improves β-cell function in T2D by reversing dedifferentiation and restoring transcription factors through FOXO1 reactivation.
bioRxiv · Feb 16, 2026 · PreprintPhysiology