Author

Nishtha Varshney

Indian Institute of Technology Kanpur

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ankur ChattopadhyayiD· 1 shared Appu Kumar SinghiD· 1 shared Kirill A. MartemyanoviD· 1 shared KV Nageswar· 1 shared Mansi SharmaiD· 1 shared Rohit Chettri· 1 shared SRISTI NANDA· 1 shared Vikesh KumariD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

Ankur ChattopadhyayORCID

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1 paper

Recent·Most cited

Unique pore architecture underlies constitutive gating of human retinalTRPM1

Mansi Sharma, KV Nageswar, Vikesh Kumar, Ankur Chattopadhyay, SRISTI NANDA, Nishtha Varshney, Rohit Chettri, Kirill A. Martemyanov, Appu Kumar Singh

The paper reports the first cryo-EM structure of human TRPM1 in a conducting state, revealing an unexpected domain-swapped pore architecture and constitutive gating mechanism.

bioRxiv · Feb 18, 2026 · PreprintBiochemistry