Developmental IL7/IL7R signaling in fetal resident tissue macrophages regulates adaptive responses to liver injury
Nicole Tseng, Gabriel Leung, Brian P Krum, Ernest M. Kameni, Clint H. Valencia, Samuel Arda, Daniel S Barrera, Noah Huerta, Patrice Nsangou Mimche, Anna E. Beaudin
This study shows that IL7/IL7R signaling during fetal development programs liver-resident macrophages, which are critical for postnatal immune responses to liver injury.
bioRxiv · Oct 31, 2026 · PreprintImmunology