Molecular mechanism by which SARS-CoV-2 Orf9b suppresses the Tom70-Hsp90 interaction to evade innate immunity
Noah Sherer, Abhishek Bastiray, Xiaoru Chen, Trivikram R. Molugu, Gaya Prasad Yadav, Tatyana I. Igumenova, Jaehyun Cho
This study identifies how SARS-CoV-2 Orf9b inhibits the Tom70-Hsp90 interaction to suppress IFN production using structural and thermodynamic analyses.
Science Advances · Jul 31, 2026Peer-reviewedBiophysics