RICO enables integrated analysis of ribosomal DNA copy number and methylation from nanopore long-read sequencing
Zaka Wing-Sze Yuen, Noemie Leeder, Thejaani P. Udumanne, Andrew Garvie, Lee H. Wong, Emiliana Weiss, Lex M. van Loon, Austen R. D. Ganley, Ross D. Hannan, Eduardo Eyras, Nadine Hein
RICO quantifies rDNA copy number and methylation using nanopore sequencing, showing accurate results in simulations and human/mouse samples, and revealing correlations between rDNA CN and methylation.
bioRxiv · Jul 6, 2026 · PreprintBioinformatics