Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated features
M. Oren, E. Domany, G. Benor, G. Fuks, O. Rueda, S.-F. Chin, C. Caldas, s. mukherjee, S. Arankar, Y. Aylon
The paper identifies a subset of human breast tumors with wild-type TP53 that exhibit gene expression and pathway patterns similar to TP53-mutated tumors, suggesting functional rewiring of p53.
Molecular Oncology · Aug 1, 2020Peer-reviewedCancer Biology