PPAR-γ regulates the effector function of human TH9 cells by promoting glycolysis
N. L. Bertschi, O. Steck, F. Luther, C. Bazzini, L. von Meyenn, A. Felser, I. Keller, O. Friedli, S. Freigang, N. Begre, C. Lamos, M. P. Gabutti, M. Benzaquen, M. Laimer, D. Simon, , C. Schlapbach
This study shows PPAR-γ promotes glycolysis in human TH9 cells, enhancing IL-9 expression and effector function through mTORC1.
bioRxiv · Aug 16, 2022 · PreprintImmunology