Selective binders of a cotranslational folding intermediate
Ohm Prakash, Tomas B Voisin, Alzbeta Roeselova, Cecilie M Jorgensen, James S Desmet, Andrea Nans, Rick Davies, Louise Jane Walport, David Balchin
The paper identifies cyclic peptides that selectively bind to a cotranslational folding intermediate of β-galactosidase, revealing a druggable pocket formed during translation.
bioRxiv · Nov 2, 2026 · PreprintBiochemistry