Louise J. Walport

The paper identifies cyclic peptides that selectively bind to a cotranslational folding intermediate of β-galactosidase, revealing a druggable pocket formed during translation.

The paper identifies a macrocyclic peptide binder, IMP2660, that disrupts RAB27A-effector interactions and enables crystallization of RAB27A without an effector, revealing its structural features.

The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

The paper investigates PADI6's role in oocyte cytoplasmic lattices using single-cell proteomics and transcriptomics, revealing its critical scaffolding function and connections to other oocyte compartments.

The paper develops cyclic peptide modulators of PADI4 and reveals their mechanism of action and cellular activity.

This study determines the crystal structure of human PADI6, revealing structural differences that suggest it lacks catalytic activity compared to other PADIs.

The paper describes a method to identify cyclic peptides targeting the BRD3 extraterminal domain using mRNA display in cell lysates, expanding the scope of target proteins for screening.