Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivity.
M. Kjolby, P. Breining, K. M. Pedersen, N. Wellner, K. M. J. Sorensen, A. M. P. Gjessing, D. Januliene, D. M. Vittrup, A. Manavalan, M. Rotman, G. Thotakura, G. Hermey, P. Madsen, C. B. Vaegter, S. Thirup, , A. Nykjaer
This study identifies sol-SorCS1 as a soluble form of SorCS1 that enhances insulin sensitivity by binding the insulin receptor, improving glucose uptake and signaling in myocytes.
bioRxiv · Nov 10, 2020 · PreprintPhysiology