Promising Antimalarials targeting Apicoplast DNA Polymerase from Plasmodium falciparum
P. Cheda, N. Nieto, S. Kaur, J. M. Beck, J. R. Beck, R. Kerns, R. B. Honzatko, S. W. Nelson
The paper identifies key structural motifs for inhibiting apicoplast DNA polymerase (apPOL) and validates it as an antimalarial target.
bioRxiv · Mar 7, 2022Biochemistry