S. Kaur

Exploring the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cells

This study investigates the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cells, finding CaMK2-dependent insulinotropic effects but limited cytoprotection and transcriptomic modulation.

Propidium monoazide is unreliable for quantitative live-dead molecular assays

This study shows that propidium monoazide (PMA) is unreliable for quantitative viability assays when bacterial concentration and composition are unknown, but suitable for qualitative assessment with known dead microbes or extracellular DNA.

A Mechanically Resilient Soft Hydrogel Improves Drug Delivery for Treating Post-Traumatic Osteoarthritis in Physically Active Joints

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

A dissection of the genomic antimicrobial resistance epidemiology of Salmonella Typhimurium

The paper analyzes antimicrobial resistance in Salmonella Typhimurium using genomic data to identify resistant strains and their geographic and host associations.

Wheat Enhanced Disease Resistance EMS-Mutants Include Lesion-mimics With Adult Plant Resistance to Stripe Rust

The paper identifies 16 wheat mutants with enhanced resistance to stripe rust and other fungal pathogens through forward genetic screening and maps their mutations to a long-read genome.

Characterising Staphylococcus aureus genomic epidemiology with Multilevel Genome Typing.

This study develops a multilevel genome typing (MGT) scheme for Staphylococcus aureus to characterize genomic epidemiology at various scales using 50,481 genomes.

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Delta/+ mice hearts

Beta-Cell Pyroptosis - A Burning Flame in Type 1 Diabetes?

This paper challenges the dogma that beta-cell death in T1D is primarily apoptotic by presenting evidence for pyroptosis as a key mechanism driving islet inflammation and beta-cell demise.

A portable, easy-to-use paper-based biosensor for rapid in-field detection of fecal contamination on fresh produce farms

The paper develops a portable paper-based LAMP biosensor for rapid on-farm detection of fecal contamination using Bacteroidales as a biomarker, achieving 100% concordance with lab tests.

A Drug-Free Pathogen Capture and Neutralizing Nasal Spray to Prevent Emerging Respiratory Infections

This paper introduces a drug-free nasal spray that captures and neutralizes respiratory pathogens, showing high efficacy in mice against influenza.

Differential regulation by CD47 and thrombospondin-1 of extramedullary erythropoiesis in mouse spleen

This study shows that CD47 and thrombospondin-1 regulate extramedullary erythropoiesis in mouse spleen, with CD47 limiting it and thrombospondin-1 supporting a basal level.

Untargeted proteomics identifies plant substrates of the bacterial-derived ADP-ribosyltransferase AvrRpm1

The paper identifies plant substrates of the bacterial ADP-ribosyltransferase AvrRpm1 using untargeted proteomics, revealing ADP-ribosylation sites on RIN4 in legumes and Arabidopsis.

A drop dispenser for simplifying on-farm detection of foodborne pathogens

The paper develops a drop dispenser for on-farm detection of foodborne pathogens using LAMP, achieving performance comparable to commercial pipettors at a low cost.

SARS-CoV-2 variants exhibit differential gut tropism and dysbiosis in Syrian golden hamsters.

This study examines SARS-CoV-2 variants' gut tropism and impact on gut microbiota in Syrian golden hamsters, finding Delta's stronger gastrointestinal preference and greater microbial dysbiosis.

Win-paired cues modulate the effect of dopamine neuron sensitization on decision making and cocaine self-administration: divergent effects across sex

This study shows that dopamine neuron sensitization interacts with win-paired cues to differentially affect risk-taking and cocaine self-administration in male and female rats.

Genomic epidemiology and multilevel genome typing of Bordetella pertussis

This paper introduces a multilevel genome typing system for Bordetella pertussis to improve surveillance and understanding of circulating strains and their public health risks.

Complete genome sequences of the species type strains Sinorhizobium garamanticum LMG 24692T and Sinorhizobium numidicum LMG 27395T and CIP 109850T

The paper reports complete genome sequences of three Sinorhizobium type strains and confirms their species status through genomic analysis.

SaLTy: a novel Staphylococcus aureus Lineage Typer

SaLTy is a new lineage typing method for Staphylococcus aureus that divides isolates into 61 phylogenetic lineages with high accuracy, improving on existing clonal complex classifications.

Characterisation of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC- βH5 beta cells

This study examines how pro-inflammatory cytokines affect EndoC-βH5 beta cells, showing increased apoptosis, mitochondrial dysfunction, and transcriptomic changes linked to type 1 diabetes.

Identification of leaf rust resistance loci in a geographically diverse panel of wheat using genome-wide association analysis

This study identifies leaf rust resistance loci in wheat using GWAS, finding 27 marker-trait associations, 20 near known resistance genes and 7 potentially novel regions.

Endothelial cells release microvesicles that harbor multivesicular bodies and secrete exosomes

The paper identifies a novel form of extracellular vesicles (MCMVs) released by endothelial cells that contain multivesicular bodies and release exosomes.

The giant diploid faba genome unlocks variation in a global protein crop

The paper presents a high-quality chromosome-scale genome assembly of faba bean and uses it to develop a genotyping assay and dissect hilum color genetics, providing a genomics-based breeding platform for sustainable protein production.

Transcriptional signature pattern in black, blue and purple wheat and impact on seed pigmentation and other associated features: Comparative transcriptomics, genomics and metabolite profiling

The paper investigates anthocyanin biosynthesis in pigmented wheat seeds using transcriptomics, genomics, and metabolite profiling to identify gene regulation patterns and their impact on seed color and traits.

Dietary αKG inhibits SARS CoV-2 infection and rescues inflamed lungs to restore normal O2 saturation in animals

This study shows dietary αKG inhibits SARS-CoV-2 infection and reduces lung inflammation and thrombosis in animals, restoring oxygen saturation.

Promising Antimalarials targeting Apicoplast DNA Polymerase from Plasmodium falciparum

The paper identifies key structural motifs for inhibiting apicoplast DNA polymerase (apPOL) and validates it as an antimalarial target.

Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase

The paper screens small-molecule libraries to identify inhibitors of Plasmodium falciparum apicoplast DNA polymerase, finding nine potent compounds that inhibit parasite growth.

Increased core body temperature exacerbates defective protein prenylation in mouse avatars of mevalonate kinase deficiency

This study shows that increased body temperature worsens protein prenylation defects in mouse models of mevalonate kinase deficiency, suggesting temperature as a trigger for inflammation.

Genomic rearrangements have consequences for introgression breeding as revealed by genome assemblies of wild and cultivated lentil species

The paper develops genome assemblies of wild and cultivated lentil species to reveal structural rearrangements affecting introgression breeding.

Temporal regulation of Pten is essential for retina regeneration in zebrafish

This study shows that Pten downregulation is essential for zebrafish retina regeneration by promoting Muller glia-derived progenitor cell proliferation through Akt and Mmp9/Notch pathways.

Alpha-ketoglutarate augments prolyl hydroxylase-2 mediated inactivation of phosphorylated-Akt to inhibit induced-thrombosis and inflammation

This study shows that alpha-ketoglutarate inhibits Akt-driven thrombosis and inflammation by enhancing PHD2 activity and reducing pAkt1 levels in platelets and leukocytes.