A receptor-independent signaling pathway for BDNF
J. Fath, F. Brouillard, A. Cabaye, D. Claverie, P. Nuss, V. Poillerat, S. Chwetzoff, T. Bouceba, E. Bouvier, M. Salameh, J. Molet, A. Padilla-Ferrer, P. Couvert, F. Acher, M.-P. Golinelli-Cohen, , C. Becker
The paper reports a receptor-independent pathway by which BDNF activates the KEAP1-NRF2 cytoprotective system by crossing the cell membrane and binding KEAP1.
bioRxiv · Aug 23, 2022 · PreprintCell Biology