C. Becker

Macrophages foster adaptive anti-tumor immunity by ZEB1-dependent cytotoxic T cell chemoattraction

This study identifies ZEB1 as a key regulator of TAM-mediated T cell trafficking, enhancing CTL recruitment and immunosurveillance in tumors and metastases.

Evolution and diversification of the momilactone biosynthetic gene cluster in the genus Oryza

The paper reconstructs the evolution and sub-functionalization of the momilactone biosynthetic gene cluster in Oryza species using comparative genomics.

The lactonase BxdA mediates metabolic adaptation of maize root bacteria to benzoxazinoids

The paper identifies BxdA, a lactonase in maize root bacteria, which enables metabolic adaptation to benzoxazinoids, enhancing bacterial growth under carbon limitation.

Haplotype independence contributes to evolvability in the long-term absence of sex in a mite

The paper identifies haplotypic independence as a mechanism enabling long-term survival of an asexual mite species without sex.

Monitoring hPSC genomic stability in the chromosome 20q region by ddPCR

The paper describes an optimized ddPCR method to detect BCL2L1 copy number increases in hPSC cultures, enabling rapid and accurate genomic stability monitoring.

The common oral parasitic protozoan Entamoeba gingivalis forms cysts in response to antibiotic treatment

This study shows that Entamoeba gingivalis forms cysts in response to antibiotic treatment, which may explain persistent periodontal tissue destruction.

Epigenetic variation in the Lombardy poplar along climatic gradients is independent of genetic structure and persists across clonal reproduction

The paper examines epigenetic variation in Lombardy poplar along climatic gradients, finding that DNA methylation correlates with climate and persists through clonal reproduction.

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

The paper uses patient-derived organoids and phosphoproteomics to study signaling crosstalk in colorectal cancer and identify off-target effects of kinase inhibitors.

A receptor-independent signaling pathway for BDNF

The paper reports a receptor-independent pathway by which BDNF activates the KEAP1-NRF2 cytoprotective system by crossing the cell membrane and binding KEAP1.

Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection

This paper develops aminoadamantane nitrate compounds that inhibit SARS-CoV-2 infection by S-nitrosylating ACE2 and blocking viral entry, showing efficacy in vitro and in a Syrian hamster model.

Genetic and environmental drivers of large-scale epigenetic variation in Thlaspi arvense

This study identifies genetic and environmental factors influencing DNA methylation variation in Thlaspi arvense across Europe, showing context-dependent associations with climate and genetic variants.

Predictable and stable epimutations induced during clonal propagation with embryonic transcription factors

The paper investigates how epigenetic modifications during clonal propagation affect phenotypic variation in Arabidopsis thaliana, showing that tissue-specific DNA methylation imprints drive these changes.

DNA methylation dynamics during stress-response in woodland strawberry (Fragaria vesca)

This study examines DNA methylation changes in woodland strawberry under various environmental stresses and identifies differentially methylated regions linked to stress-response genes.

Transcriptional response of a target plant to benzoxazinoid and diterpene allelochemicals highlights commonalities in detoxification

This study examines how Arabidopsis thaliana responds to two allelochemicals, finding similar transcriptional responses involving detoxification pathways.

MethylScore, a pipeline for accurate and context-aware identification of differentially methylated regions from population-scale plant WGBS data

MethylScore identifies differentially methylated regions in plant WGBS data using an unsupervised machine learning approach, improving statistical power and reducing false positives.

Chromosome-level Thlaspi arvense genome provides new tools for translational research and for a newly domesticated cash cover crop of the cooler climates

The paper presents a chromosome-level genome assembly of Thlaspi arvense and uses it to analyze genetic variation and gene structure differences between accessions.

Repression of CHROMOMETHYLASE 3 Prevents Epigenetic Collateral Damage in Arabidopsis

This study shows that repression of CMT3 prevents ectopic methylation of genes during Arabidopsis embryogenesis, avoiding epigenetic collateral damage.

Plant-derived benzoxazinoids act as antibiotics and shape bacterial communities

The paper investigates how benzoxazinoid derivatives affect bacterial communities in the plant rhizosphere, finding that community stability depends on isolate resilience and strain-specific interactions.

Transcriptomic profiling uncovers novel players in innate immunity in Arabidopsis thaliana

This study uses RNA-Seq to identify differentially expressed genes in Arabidopsis in response to MAMP and DAMP treatments, revealing novel genes involved in innate immunity.

Nitric oxide coordinates histone acetylation and expression of genes involved in growth/development and stress response

The paper shows that nitric oxide regulates histone acetylation and gene expression related to growth, development, and stress response in Arabidopsis thaliana.

ARADEEPOPSIS: From images to phenotypic traits using deep transfer learning

This paper introduces a deep learning-based tool for automated phenotyping of plant images, demonstrating its effectiveness in segmenting diverse genotypes and mapping genetic loci related to leaf traits.

Importance of parental genome balance in the generation of novel yet heritable epigenetic and transcriptional states during doubled haploid breeding

The paper identifies imbalanced parental genome contributions as a source of transcriptional and epigenetic variation in doubled haploid plants, revealing a role for epigenetic modification of transposons in generating heritable phenotypic diversity.

Strengths and potential pitfalls of hay-transfer for ecological restoration revealed by RAD-seq analysis in floodplain Arabis species

This study uses RAD-seq to assess how hay-transfer affects genetic diversity in floodplain Arabis species, showing it maintains diversity but with species-specific outcomes.

Incomplete reprogramming of cell-specific epigenetic marks during asexual reproduction leads to heritable phenotypic variation in plants

Ecological plant epigenetics: Evidence from model and non-model species, and the way forward

The paper reviews epigenetic contributions to plant ecology and proposes integrating model-species research with non-model species studies to better understand ecological processes.

Targeted re-sequencing reveals the genomic signatures of multiple barley domestications

This study uses targeted resequencing of barley accessions to identify genomic signatures of multiple domestications in the Levantine and Zagros regions.