Localized nanoparticle-mediated delivery of miR-29b normalises the dysregulation of bone homeostasis caused by osteosarcoma whilst simultaneously inhibiting tumour growth.
F. E. Freeman, P. Dosta, C. J. Riojas Javelly, O. R. Mahon, D. Kelly, N. Artzi
This study delivers miR-29b via nanoparticles to treat osteosarcoma, reducing tumour burden and improving bone homeostasis when combined with chemotherapy.
bioRxiv · Sep 9, 2022 · PreprintBioengineering